Harry's Seafood Bar & Grille

Located in the heart of Gainesville, Florida, Harry's Seafood Bar & Grille serves up an irresistible taste of the Gulf Coast with its vibrant seafood and Cajun-inspired bar & grill fare. This lively restaurant offers a warm and inviting atmosphere perfect for everything from casual lunches to celebratory dinners, making it a favored destination among locals and visitors alike. Whether you're seated at the bustling bar during happy hour or at a cozy table overlooking SE 1st Street, the energy is consistently welcoming and upbeat.

The menu at Harry's is a treasure trove of Southern seafood classics and inventive dishes that delight the palate at every turn. Guests rave over signature highlights like the Fried Green Tomatoes, crisp and tangy with a perfect balance, and the Shrimp & Scallop Orleans, bursting with bold, authentic Cajun spices. For a richer, heartier experience, the Andouille Crusted Grouper and Harry's Signature Crab Cakes stand out — both executed with impeccable freshness, allowing the delicate flavors of quality seafood to shine through with every bite.

The restaurant’s playful nod to Southern street food can be savored through their signature handhelds such as the Jazzy Chicken Tacos, where crispy fried chicken bites are tossed in a spicy sriracha aioli and harmoniously paired with fresh pico de gallo and blended cheeses. The Shrimp Po’ Boy offers a mouthwatering crunch on French bread, dressed with cool, crisp lettuce, tomato, and pico, transporting diners directly to a Gulf Coast marketplace.

No visit would be complete without indulging in dessert, where Harry's brilliantly combines familiar comforts with flavorful twists. The Key Lime Pie, served cool and refreshing, is a standout, boasting their personal recipe that’s both tart and creamy. Equally decadent are the Oreo Beignets — six classic Oreo cookies fried to light, fluffy perfection and drizzled with white chocolate bourbon sauce and chocolate syrup, a luxurious finale that will satisfy any sweet tooth.

Patrons consistently commend Harry's for its superb service and vibrant, friendly ambiance. One guest highlighted the attentive care provided by the staff, noting how their server’s warm professionalism elevated their evening. Another reviewer praised the generous portions and value, emphasizing the distinct flavors in dishes like Shrimp & Grits and Honey Bourbon Glazed Salmon. The restaurant also shines with its Bourbon Street favorites — from Chicken N Grits with a creamy tasso ham sauce to the iconic Jambalaya and Red Beans & Rice with smoked sausage — each delivering the rich, soulful taste of Louisiana’s culinary heritage.

While a rare misstep was noted with a raw grouper steak, it’s clear that Harry's dedication to freshness and quality typically wins the day. Many diners attest to the consistently fresh and delicious offerings, often returning for the perfectly cooked seafood, vibrant flavors, and the overall joyful dining experience.

Whether you’re craving the zest and heat of Cajun spices, the comforting allure of Southern staples, or just a relaxed spot to enjoy expertly crafted cocktails like their refreshing mojitos, Harry’s Seafood Bar & Grille delivers an authentic and memorable meal. For those visiting Gainesville, this restaurant is a must-try — a place where every bite tells a story of rich culinary tradition and every gathering feels like a celebration.

Contact: 110 SE 1st St, Gainesville, FL 32601 | Phone: +1 352-372-1555